Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.
نویسندگان
چکیده
منابع مشابه
Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.
This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screening criterion. Of 800 EMS-induced lethal mutations analyzed, only 14% were embr...
متن کاملSpontaneous and ethyl methanesulfonate-induced mutations controlling viability in Drosophila melanogaster. I. Recessive lethal mutations.
The efficiency of the adult feeding method for EMS treatment in Drosophila melanogaster was studied by measuring the frequency of induced recessive lethals on the second chromosome. The treatment was most effective when mature spermatozoa or spermatids were treated and was much less effective on earlier stages. The number of mutations induced was proportional to the concentration except at the ...
متن کاملMale-specific lethal mutations of Drosophila melanogaster.
A total of 7,416 ethyl methanesulfonate (EMS)-treated second chromosomes and 6,212 EMS-treated third chromosomes were screened for sex-specific lethals. Four new recessive male-specific lethal mutations were recovered. When in homozygous condition, each of these mutations kills males during the late larval or early pupal stages, but has no detectable effect in females. One mutant, mlets, is a t...
متن کاملStudy on KAL1 Gene Mutations in Idiopathic Hypogonadotropic Hypogonadism Patients with X-Linked Recessive Inheritance
Idiopathic hypogonadotropic hypogonadism (IHH) is a condition caused by low doses of hypothalamic gonadotropin-releasing hormone (GnRH) leading to absence or incomplete sexual maturation. One of the disorders leading to IHH is Kallmann syndrome which is characterized by GnRH deficiency with anosmia or hyposmia. This disorder generally occurs as a hereditary syndrome with X-linked recessive inhe...
متن کاملInteractions between Some Recessive Lethal and Visible Mutations of the Fourth Chromosome of Drosophila Melanogaster.
XPERIMENTAL populations of Drosophila melunoguster kept by DR. BRUCE E WALLACE and his collaborators (1951) received chronic radiation of approximately 2,000r per generation. The effect on the fourth chromosome was analyzed by these investigators by outcrossing males from the irradiated populations with females carrying the dominant mutations, “cubitus interruptus” (ci”) and “eyeless” (ey”) as ...
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ژورنال
عنوان ژورنال: Genetics
سال: 1988
ISSN: 1943-2631
DOI: 10.1093/genetics/118.1.109